Background

Since the begining of the last century much attention has been focused on tumour vascularization.

Warren Lewis⁽¹⁾, in 1922, and Gordon Ide, in 1939⁽²⁾, had already considered the hypothesis of synthesis of a vascular growth factor by tumour cells.

Synthesis of a vascular growth factor in the retina was proposed for the first time in 1948⁽³⁾, in diabetic eyes by Isaac Michelson.

Introduction

In recent years, new treatment modalities such as photodynamic therapy and intravitreal anti-VEGF injections have been added to the treatment armamentarium for age-related macular degeneration (AMD).

Introduction

Optical coherence tomography (OCT) technology allows the acquisition of cross-sectional images of the retina with semihistologic resolution.

It permits to define the location and nature of the changes in the retina and adjacent structures and objectively evaluates the thickness of the retina and surrounding structures.

These capabilities allow detection of newly emerging fluid and/or intraretinal or subretinal tissue and tissue below the retinal pigment epithelium
c. Neurosensory Retinal Detachment (RPE).

1. BACKGROUND

The advent of optical coherence tomography (OCT) revolutionized retinal imaging by providing a fast, simple, and noninvasive method to assess retinal structure at a microscopic level.⁽¹⁾